My grandma likes to sit at a casino all day and play nickel slots. She has hit a few pots worth like 100-500.00. Is that considered a big jackpot on nickel slots? Has anyone here won a big jackpot on a nickel slot machine. I played some nickel slots for a while in New Mexico last time I was there and I lost most of my money if I remember correctly. Then I switched to Blackjack and won it back and then some.